01-P010 Prader–Willi Syndrome and small nucleolar RNAs
نویسندگان
چکیده
01-P007 Characterising microRNA expression and function during embryonic gonadal development Stephanie Bannister, Henk Buermans, Ivano Broz, Mark Tizard, Timothy Doran, Andrew Sinclair, Craig Smith Livestock Industries, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australian Animal Health Laboratory, Geelong, Vic., Australia Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, Netherlands Murdoch Children’s Research Institute, Royal Children’s Hospital, Parkville, Vic., Australia Department of Paediatrics, The University of Melbourne, Parkville, Vic., Australia
منابع مشابه
A computational screen for C/D box snoRNAs in the human genomic region associated with Prader-Willi and Angelman syndromes.
Small nucleolar RNAs (snoRNAs) play a significant role in Prader-Willi Syndrome (PWS) and Angelman Syndrome (AS), which are genomic disorders resulting from deletions in the human chromosomal region 15q11-q13. To identify snoRNAs in the region, our computational study employs key motif features of C/D box snoRNAs and introduces a complementary RNA-RNA hybridization test. We identify three previ...
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Small nucleolar RNAs (snoRNAs) are molecules located in the cell nucleolus and in Cajal bodies. Many scientific reports show that snoRNAs are not only responsible for modifications of other RNAs but also fulfill multiple other functions such as metabolic stress regulation or modulation of alternative splicing. Full-length snoRNAs as well as small RNAs derived from snoRNAs have been implied in h...
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The SNORD116 small nucleolar RNA locus (SNORD116@) is contained within the long noncoding RNA host gene SNHG14 on human chromosome 15q11-q13. The SNORD116 locus is a cluster of 28 or more small nucleolar (sno) RNAs; C/D box (SNORDs). Individual RNAs within the cluster are tandem, highly similar sequences, referred to as SNORD116-1, SNORD116-2, etc., with the entire set referred to as SNORD116@....
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Imprinting, non-coding RNA and chromatin organization are modes of epigenetic regulation that modulate gene expression and are necessary for mammalian neurodevelopment. The only two known mammalian clusters of genes encoding small nucleolar RNAs (snoRNAs), SNRPN through UBE3A(15q11-q13/7qC) and GTL2(14q32.2/12qF1), are neuronally expressed, localized to imprinted loci and involved in at least f...
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ورودعنوان ژورنال:
- Mechanisms of Development
دوره 126 شماره
صفحات -
تاریخ انتشار 2009